We are seeking a Senior Scientist to join our Protein Development group. This position will be focused on expression and purification of proteins to support the efforts of Regeneron's structural biology group in X-ray crystallography and cryo-electron microscopy (cryoEM). You will work closely with scientists in the structural biology group to develop purification procedures to deliver highly pure and homogeneous protein samples. The proteins in question will be very diverse, including soluble proteins, integral membrane proteins, multi-protein complexes, antibodies, engineered constructs, etc. Most will be human in origin, and in most cases only the human protein will do - we will not have the luxury of testing other species for better behaved homologues. Integral membrane proteins will need to be solubilized using various techniques drawn from the structural biology literature, including detergents, amphipols, and nanodiscs.
As a Senior Scientist, a typical day might include:
Designing and conducting protein expression and purification protocols
Optimizing experimental procedures, drawing on available literature and previous results
Thinking about new approaches to get around an obstacle with current expression or purification efforts
Presenting results and discussing plans with a variety of audiences, from small core teams all the way to VP-level meetings
This role may be for you if you have:
Creativity and the ability to apply novel strategies to address complex questions
The desire and ability to work on multiple projects in parallel in a fast-paced, team environment
A passion for science and innovation with a strong dedication to continual improvement
Can work both independently and collaboratively within the group, as well as cross-functionally
In order to be considered for this role, you must have at least a Ph.D. with 0-2 years post degree or a BS/MS and 8+ years of relevant experience in membrane protein biochemistry, structural biology, or a related field. You should have substantial protein expression and purification experience in a number of different systems (bacterial, insect, and/or mammalian cells; membrane vs. soluble proteins; multi-protein complexes; etc.) Experience with tissue culture is preferred. Innovation at this stage may save a lot of time in later experiments, so creativity and trying new ideas will be a key part of the job duties.
Does this sound like you? Apply now to take your first steps toward living the Regeneron Way! We have an inclusive and diverse culture that provides comprehensive benefits including health and wellness programs, fitness centers and equity awards, annual bonuses, and paid time off for eligible employees at all levels!
Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, nationality, national or ethnic origin, civil status, age, citizenship status, membership of the Traveler community, sexual orientation, disability, genetic information, familial status, marital or registered civil partnership status, pregnancy or parental status, gender identity, gender reassignment, military or veteran status, or any other protected characteristic in accordance with applicable laws and regulations. We will ensure that individuals with disabilities are provided reasonable accommodations to participate in the job application process. Please contact us to discuss any accommodations you think you may need.
The salary ranges provided are shown in accordance with U.S. law and apply to U.S. based positions, where the hired candidate will be located in the U.S. If you are outside the U.S, please speak with your recruiter about salaries and benefits in your location.
Salary Range (annually)