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Sr Principal Scientist, Protein Biochemistry

Job Description

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The Protein Biochemistry Group is seeking a highly motivated Sr. Principal Scientist to lead the molecular profiling, developability and characterization of therapeutic proteins, representing a variety of structures. You will be supporting the characterization of novel modalities such as gene therapy agents and oligonucleotides as well as complex therapeutic strategies and approaches. The qualified candidate will also be responsible for recommending, adapting and developing analytical methods for protein characterization.

You must have in-depth knowledge of macromolecular physical chemistry especially solution interactions and hands-on experience in protein characterization using a variety of analytical tools. The candidate is encouraged to be proficient with experimental design and an effective communicator of ideas, project goals and results to team members within the group and with colleagues in collaborating departments. You will proactively identify issues and develop solutions in a collaborative multidisciplinary environment is crucial. The successful candidate is expected to also lead and build an effective team of scientists and be responsible their career development.

A day as a Sr. Principal Scientist looks like:

  • Participates in and leads all aspects of protein or new modality characterization to provide molecular profiles and developability assessments of therapeutic assets, that support the pipeline, in a timely manner and aligned with partner functions.
  • Reviews the literature and, drawing on in-depth knowledge and experience, designs experiments that solve biophysical problems for key collaborators. Has fundamental knowledge of assay qualification and statistical experimental design and decision making.
  • Supervises and supports junior scientists with critical data review as well as career development. Builds an effective molecular characterization team.
  • Ability and enthusiasm for independently learning new methods and softwares. Is a go-to resource for explaining and solving biophysical problems.
  • Provides biophysical support and analytical development for both upstream and downstream functional groups; helps solve problems in real-time.
  • Practical knowledge of downstream purification and formulation development of biologics and drug product profiles aligned with therapeutic strategies.
  • Has generally good technical writing skills. Documents experiments, results and findings in electronic laboratory notebook; presents work at group and department meetings; contributes to drafting of analytical characterization reports, regulatory submission sections, and peer-reviewed articles for publication.
  • May serve as a team representative in drug candidate-specific development team meetings, and share knowledge and expertise of biophysical chemistry at cross-function team meetings.
  • -Understands how to strategically position internal characterization efforts and collaborations within Protein Biochemistry and with Regeneron partner groups for optimum visibility.

This role may be for you if you have:

  • Have excellent written and verbal communication skills. The successful candidate must be able to prepare slides, author reports and manuscripts for internal and external presentations, and peer-reviewed publications.‚Äč
  • The desire and ability to work in a team environment. A passion for science and innovation with a strong commitment to continual improvement and making significant contributions.
  • Experience demonstrating broad, in-depth knowledge of macromolecular solution chemistry and biophysics and how this applies to proteins, polymers, viruses, particles and nucleic acids.
  • Experience designing and solve analytical methods and demonstrate the ability to plan, design, implement laboratory experimentation to advance projects. Experience with statistical and experimental design, molecular modeling, graphing and mathematical analysis softwares is a plus.

In order to be considered qualified for this role, you must have aPhD in pharmaceutical sciences, biophysics, biochemistry, chemical engineering or equivalent with at least 5 years post-doctoral training combined with industry experience in characterization of therapeutic protein candidates (and/or AAVs, oligonuceleotides). Knowledge of and demonstrated expertise operating light scattering, liquid chromatography, and capillary electrophoresis instrumentation is essential. Experience in spectroscopic (e.g. CD, fluorescence, and/or FTIR) principles and applications for analysis of proteins, size-based (AUC, LC, MALS) and charge-based (e.g. icIEF, IEX) separation techniques is important. In-silico modeling skills are a bonus.


Does this sound like you? Apply now to take your first steps toward living the Regeneron Way! We have an inclusive and diverse culture that provides comprehensive benefits including health and wellness programs, fitness centers and equity awards, annual bonuses, and paid time off for eligible employees at all levels!
Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, nationality, national or ethnic origin, civil status, age, citizenship status, membership of the Traveler community, sexual orientation, disability, genetic information, familial status, marital or registered civil partnership status, pregnancy or parental status, gender identity, gender reassignment, military or veteran status, or any other protected characteristic in accordance with applicable laws and regulations. We will ensure that individuals with disabilities are provided reasonable accommodations to participate in the job application process. Please contact us to discuss any accommodations you think you may need.
The salary ranges provided are shown in accordance with U.S. law and apply to U.S. based positions, where the hired candidate will be located in the U.S. If you are outside the U.S, please speak with your recruiter about salaries and benefits in your location.

Salary Range (annually)

$141,800.00 - $231,400.00