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Scientist- Clinical Tissue Biomarker & Histological Analysis

Job Description

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We are seeking a passionate and highly motivated Scientist to join our Clinical Histology Core. We need someone with extensive experience with immunohistochemistry assays and chromogenic-/fluorescent IHC & ISH multiplexing. You will be a part of a multidisciplinary team dedicated to developing, implementing, and applying novel histology-based transcriptomics and proteomics techniques to drive and support clinical biomarker strategies and research programs across different disease areas.

As a Scientist, a typical day might include the following:

  • Proactively screening the market and scientific landscape for new innovative tissue-based methods and technologies.

  • Leading technology evaluation, planning, and performing pilot studies, as well as integrating valuable technologies into the existing infrastructure

  • Designing, developing, optimizing, validating, and performing novel tissue-based multi- & high-plex IHC and ISH protocols and techniques

  • Performing automated chromogenic/fluorescent IHC and ISH as well as Hematoxylin Eosin staining’s using different tissue staining platforms (e.g. Ventana Discovery, Leica Bond)

  • Evaluating and validating new antibodies for single, multi- and high-plex IHC protocols

  • Sectioning of FFPE and frozen tissue samples using manual, semi-automated, and fully automated devices

  • Applying of latest whole slide image scanner technology to digitalize histology slides and QC quality of obtained image data

  • Performing and supporting quantitative image analysis of clinical tissue samples to investigate target(s) expression and distribution

  • Authoring comprehensive and integrated development, validation, and technical reports and preparing results and present findings at internal meetings and conferences

  • Implement new state-of-art tissue analysis methods and technologies

This role might be for you if you:

  • Have strong analytical and problem-solving skills and are eager to learn new methods and technologies

  • Have the ability to work as collaboratively in a fast-paced matrix environment

  • Highly organized with attention to details as well as excellent written, verbal, and presentation skills

  • Demonstrated ability to work independently and in a team environment, working on multiple projects with evolving priorities and deadlines

  • Have excellent verbal and written communication skills, strong organizational skills, and are comfortable presenting scientific results to project teams

In order to be considered for this role, you must have at least a BS/MS with a degree in pathology, molecular pathology, biological sciences or related biomedical life sciences field and at least 5-7+ years of relevant experience in industry or academic pathology lab setting. We need someone with thorough knowledge and extensive hands-on experience in sectioning and processing of human tissue samples, selection, evaluation, and validation of IHC antibodies, development and validation of multi- and high-plex IHC assays, and automated chromogenic/fluorescent IHC and ISH staining techniques and platforms. Experience in digital pathology and image analysis (e.g. HALO software or Visiopharm) is highly desirable. Knowledge and hands-on experience with spatial transcriptomics techniques (e.g. CosMx, Xenium) is of great advantage.

Does this sound like you? Apply now to take your first steps toward living the Regeneron Way! We have an inclusive and diverse culture that provides comprehensive benefits including health and wellness programs, fitness centers and equity awards, annual bonuses, and paid time off for eligible employees at all levels!
Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, nationality, national or ethnic origin, civil status, age, citizenship status, membership of the Traveler community, sexual orientation, disability, genetic information, familial status, marital or registered civil partnership status, pregnancy or parental status, gender identity, gender reassignment, military or veteran status, or any other protected characteristic in accordance with applicable laws and regulations. We will ensure that individuals with disabilities are provided reasonable accommodations to participate in the job application process. Please contact us to discuss any accommodations you think you may need.
The salary ranges provided are shown in accordance with U.S. law and apply to U.S. based positions, where the hired candidate will be located in the U.S. If you are outside the U.S, please speak with your recruiter about salaries and benefits in your location.

Salary Range (annually)

$88,500.00 - $144,500.00