Senior Scientist, in vivo - Cancer Immunology

Summary:

We are seeking a skilled and driven Ph.D. scientist with a proven background in tumor immunology, autoimmunity, or both to join our Immunology and Inflammation team. Our team contributes to discovery and development of novel therapeutics in the Cancer Immunology group at Regeneron.

In this role, you will be responsible for designing and executing a variety of cell-based immunological assays and in vivo experiments using tumor and autoimmune mouse models. This role will employ industry-leading technologies to address pertinent questions in cancer immunology and autoimmunity.

Please see our relevant published work:

Waite JC et al., Sci. Transl. Med. (2020). DOI: 10.1126/scitranslmed.aba2325

Skokos D et al., Sci. Transl. Med. (2020). DOI: 10.1126/scitranslmed.aaw7888

As a Senior Scientist in the Cancer Immunology team, a typical day might include the following:

• Developing, optimizing, and performing various immunoassays to evaluate therapeutic candidates' impact on immune cell function and phenotype, including advanced techniques such as multicolor flow cytometry and fluorescence microscopy.

• Independently planning and executing in vivo studies using tumor and autoimmune mouse models. These will include treatments with injections through various routes (IP, IV, SC), blood and tissue collection for downstream analysis of immune responses.

• Analyzing data using biological and statistical software such as OMIQ, Prism, Excel, etc.

• Collaborating with cross-functional scientists to drive target validation and therapeutic antibody development.

• Delivering impactful presentations to colleagues across our business, including senior leadership.

• Writing protocols and study reports, maintaining accurate electronic records.

• Routinely reviewing relevant literature, attending scientific meetings, and improving expertise in the field of Immunology and Immuno-Oncology.

• Training and management of research associates as needed.

This role might be for you if you:

• Get excited about developing immunotherapies that promote a tumor-specific and durable immune response to eradicate cancer for patients.

• Have a passion for innovation and desire to lead new scientific directions.

• Are a team player with a collaborative spirit.

• Possess excellent communication, organization, and time management skills.

• Independently design and execute experiments, analyze data, and interpret results.

• Are confident with multitasking and managing multiple projects simultaneously.

This role requires a Ph.D. in immunology, immuno-oncology, or a related field with a strong record of innovation and publication. Proven expertise in T cell biology with experience using mouse tumor and autoimmune models, including high dimensional immunophenotyping, is required. Proficiency with fluorescence microscopy and advanced imaging techniques is a plus.