Scientist, in vivo - Cancer Immunology

Summary:

We are seeking a highly motivated and dedicated bench scientist to join our Immunology and Inflammation team. Our team contributes to discovery and development of novel therapeutics in the Cancer Immunology group at Regeneron.

In this role, you will be responsible for carrying out a variety of cell-based immunological assays and in vivo experiments using tumor and autoimmune mouse models. As a member of our team, you will apply innovative technologies to address pertinent questions in cancer immunology and autoimmunity.

Please see our relevant published work:

Waite JC et al., Sci. Transl. Med. (2020). DOI: 10.1126/scitranslmed.aba2325

Skokos D et al., Sci. Transl. Med. (2020). DOI: 10.1126/scitranslmed.aaw7888

As a Scientist in the Cancer Immunology team, a typical day might include the following:

• Planing and executing in vivo studies using mice with induced or spontaneous tumor and autoimmune disease models.

• Performing injections through various routes (intraperitoneal, intravenous, subcutaneous).

• Collecting blood and isolating mouse tissues.

• Isolating immune cells from mouse and human tissues for further functional and phenotypic characterization.

• Performing ex-vivo immunophenotyping using multicolor flow cytometry.

• Designing and executing in vitro cell-based functional assays using primary or engineered cells (molecular biology assays such as ELISA/MSD, ELISPOT, RT-PCR, flow cytometry, immune cell proliferation/cytotoxicity assay and immunofluorescence imaging).

• Maintaining and culturing cells as necessary.

• Analyzing data using FlowJo, Microsoft Excel and GraphPad Prism.

• Developing new methods or technologies, and troubleshoot experiments.

• Write protocols and study reports, produce, and maintain accurate electronic records.

• Communicate findings to peers and management at various group and cross functional meetings.

This role might be for you if you:

• Enjoy working in a fast-paced environment.

• Learn quickly and have desire to expand your skill set with new techniques.

• Are detail oriented, well-organized and can multi-task effectively.

• Are a team player with a collaborative spirit.

• You have strong communication skills.

To be considered for this opportunity you must have a Bachelor's or Master's degree in Immunology, Bioengineering or related fields with at least 4 years of experience working in an immunology or cancer biology laboratory. Experience conducting experiments using mouse models with training in proper handling and care of mice. Experience in tissue culture and cell-based assays, including flow cytometry. Proficient computer skills and experience collecting and analyzing biological data.