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Sr. Scientist, Protein Biochemistry

Job Description

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The Protein Biochemistry Group is seeking a bioanalytical chemist to support quantification and characterization of novel therapeutic modalities using innovative technologies. You will be responsible for developing analytical methods and providing in-depth biophysical and biochemical characterization of gene therapy and protein-based therapeutics to support programs in late stage research through IND. The ideal candidate will have in-depth knowledge of macromolecular chemistry; hands-on experience in gene therapy and protein characterization using a variety of analytical tools for solution-based analyses is preferred. Be an effective communicator of ideas, project goals and results to team members within the group and with colleagues in collaborating departments. The ability to proactively identify issues and develop solutions in a collaborative multidisciplinary environment is essential. You will be expected to assume a leading role to deepen our knowledge of therapeutics to support R&D activities and regulatory applications.

A typical day as a Sr. Scientist looks like:

  • Independently designs and develops appropriate, fit-for purpose analytical methods for characterization and quantitation of gene therapy and protein-based candidates and/or products.
  • Fundamental knowledge of assay qualification and statistical experimental design and decision making.
  • Ability and enthusiasm for independently learning new methods and softwares.
  • Provides biophysical support and analytical development for both upstream and downstream functional groups; helps solve problems in real-time.
  • Takes a leading role in efforts to characterize various modalities to support regulatory filings and develop analytical methods within specified timelines.
  • Documents experiments, results and findings in electronic laboratory notebook; presents work at group and department meetings; contributes to drafting of analytical characterization reports, regulatory submission sections, and peer-reviewed articles for publication.
  • May serve as a team representative in drug candidate-specific development team meetings, and share knowledge and expertise of biophysical chemistry at cross-function team meetings.
  • Will likely serve in matrix-based team within Protein Biochemistry to assist in characterization efforts.
  • May provide some assistance to research associates conducting research and developmental work.
  • Participates in the general lab and instrument maintenance.

This role may be for you if:

  • You must demonstrate broad, in-depth knowledge of macromolecular solution chemistry and biophysics and how this applies to proteins, polymers, viruses, particles and nucleic acids.
  • You have excellent written and verbal communication skills. The successful candidate must be able to prepare slides, author reports and manuscripts for internal and external presentations and peer-reviewed publications.
  • You can demonstrate the ability to plan, design, implement and analyze laboratory experimentation to advance projects. Experience with statistical and experimental design, molecular modeling, graphing and mathematical analysis softwares is a plus.
  • Demonstrate ability to develop and troubleshoot analytical methods.
  • The desire and ability to work in a team environment. A passion for science and innovation with a strong commitment to continual improvement and making significant contributions in a collaborative environment.

In order to be considered, you must have PhD in analytical chemistry, biophysics, biochemistry, pharmaceutical sciences, chemical engineering or equivalent with 0-4 years post-doctoral training or combined with 0-4 years of industry experience in analytical characterization of proteins, AAVs, oligonucleotides; additionally, candidates with a BS with 10 years industry experience or MS/MA with 8 years of relevant experience will be considered. Prior experience in or collaboration with the biopharmaceutical industry is highly preferred.

Preferred knowledge of operating light scattering, liquid chromatography, and capillary electrophoresis instrumentation is crucial. Experience in spectroscopic (e.g. CD, fluorescence, and/or FTIR) principles and applications for analysis of proteins, size-based (AUC, LC, MALS) and charge-based (e.g. icIEF, IEX) separation techniques is important. Experience with binding kinetics and thermodynamics applications (BLI, SPR, ITC) is preferred. Experience with advanced analytics such as MS techniques and/or NMR is a bonus.


Does this sound like you? Apply now to take your first steps toward living the Regeneron Way! We have an inclusive and diverse culture that provides comprehensive benefits including health and wellness programs, fitness centers and equity awards, annual bonuses, and paid time off for eligible employees at all levels!
Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, nationality, national or ethnic origin, civil status, age, citizenship status, membership of the Traveler community, sexual orientation, disability, genetic information, familial status, marital or registered civil partnership status, pregnancy or parental status, gender identity, gender reassignment, military or veteran status, or any other protected characteristic in accordance with applicable laws and regulations. We will ensure that individuals with disabilities are provided reasonable accommodations to participate in the job application process. Please contact us to discuss any accommodations you think you may need.
The salary ranges provided are shown in accordance with U.S. law and apply to U.S. based positions, where the hired candidate will be located in the U.S. If you are outside the U.S, please speak with your recruiter about salaries and benefits in your location.

Salary Range (annually)

$103,600.00 - $169,000.00