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Sr. Scientist (T cell Immunology of Genetic Medicines)

Job Description

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The Enzyme Replacement Therapy group, part of Regeneron Genetic Medicines, is seeking a Senior Scientist to develop novel therapeutics to improve the safety and efficacy of viral and nonviral genetics medicines. This work would involve developing in vitro and in vivo models to elucidate immune signaling pathways involved in gene therapies and evaluating therapeutic candidates in these models. A strong emphasis on creativity and ingenuity to challenge existing dogmas and investigate unsolved problems in genetics medicines will be required. Your immunology expertise combined with Regeneron’s technology platforms, including viral and non-viral gene therapy, CRISPR-mediated gene editing, VelociGene transgenic mouse models, and the extensive catalog of fully human therapeutic antibodies, will be used to make immediate contributions to the field of immunology of genetics medicines.

As a Sr. Scientist, a typical day may include the following:

  • Design, perform, analyze, and troubleshoot in vitro and in vivo mouse experiments to investigate and validate therapeutic targets

  • Design, coordinate, analyze large animal model immunology-focused experiments with external vendors to inform clinical program development

  • Design and run animal/human ELISpots, immunophenotyping, and other relevant T cell assays

  • Collaborate with team members and provide immunological wisdom

  • Provide occasional experimental support for existing late-stage preclinical assets in the pipeline

  • Participate and present in departmental meetings and external conferences

This role may be for you if:

  • You enjoy working in an innovative and cross-functional team.

  • You have a passion for championing new immunomodulatory therapeutics.

  • You have strong organizational, time-management, and communication skills.

  • You can effectively and rationally balance and prioritize multiple projects.

This role requires a Ph.D. in immunology or a related field or a B.S./M.S. with 10 years in an immunology-focused role. A strong background in in vivo T cell biology with experience in both humans and mouse models. Experience in developing and running immune functional assays of primary human blood/tissue products is highly desired. Familiarity with the unique challenges of immune responses in gene therapies and gene editing are a plus.



Does this sound like you? Apply now to take your first steps toward living the Regeneron Way! We have an inclusive and diverse culture that provides comprehensive benefits including health and wellness programs, fitness centers and equity awards, annual bonuses, and paid time off for eligible employees at all levels!
Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, nationality, national or ethnic origin, civil status, age, citizenship status, membership of the Traveler community, sexual orientation, disability, genetic information, familial status, marital or registered civil partnership status, pregnancy or parental status, gender identity, gender reassignment, military or veteran status, or any other protected characteristic in accordance with applicable laws and regulations. We will ensure that individuals with disabilities are provided reasonable accommodations to participate in the job application process. Please contact us to discuss any accommodations you think you may need.
The salary ranges provided are shown in accordance with U.S. law and apply to U.S. based positions, where the hired candidate will be located in the U.S. If you are outside the U.S, please speak with your recruiter about salaries and benefits in your location.

Salary Range (annually)

$103,600.00 - $169,000.00